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Current research projects in 'All regions'

Institute Grant Holder Description
Barts and the London Hospital Dr John Marshall Effects of integrin ávâ6 expression on HER2-dependent breast cancer cell behaviour
Barts and the London Hospital Dr Kairbaan Hodivala-Dilke Elucidating the role of FAK in breast cancer angiogenesis
Barts and the London Hospital Dr Kairbaan Hodivala-Dilke Understanding the of Ribosomal protein L29 (RPL29) in breast cancer angiogenesis
Barts and the London Hospital Dr Stephanie Kermogant Spatio-temporal c-Met signalling in breast cancer
Barts and the London Hospital Professor Louise Jones Functional and clinical significance of loss of the tumour-suppressor MMP-8 in myoepithelial cells of DCIS
Barts and the London School of Medicine and Dentistry Dr Angelo Scibetta Role of the transcription factor AP-2 gamma in breast cancer
Brunel University Dr Amanda Harvey Regulating breast tumour cell survival through Bcl-x proteins: implications for therapeutic responses.
Cambridge Research Institute Dr Jason Carroll Characterising TLE1 as a Pioneer factor in Oestrogen Receptor action
Clare Hall Laboratories (Cancer Research UK), South Mimms Dr Stephen West Role of GEN1 in DNA Repair: A Novel Breast Cancer Tumour Suppressor?
Guy's Hospital, London Dr Joy Burchell Interactions of tumour-associated immunogenic glycoforms of MUC1 with lectins of the immune system
Guy's Hospital, London Dr Joanna Morris Role of de-ubiquitinating enzymes and ubiquitin binding proteins in breast tumourigenesis
Imperial College Dr Amin Hajitou Vascular-targeted molecular imaging and therapy of breast cancer
Imperial College Professor Stephan Grimm Mitochondrial apoptosis inhibitors as therapeutic targets in estrogen receptor-negative breast cancer
Imperial College Dr James Flanagan Germline epigenetic alterations as a mechanism for carcinogenesis
Imperial College Dr Simak Ali Mechanisms by which the estrogen receptor represses gene expression
Imperial College Professor Stephan Grimm Specific protein stabilisation for apoptosis induction in breast cancer
Institute of Cancer Research, London Professor Alan Ashworth Intermediate phenotypes and mapping causal variants: IGFBP-2, IGFBP-5 and breast cancer risk
Institute of Cancer Research, London Professor Clare Isacke Identification and characterisation of novel therapeutic targets in breast cancer metastasis
Institute of Cancer Research, London Dr Janine Erler The role of LOXL2 in breast cancer
Institute of Cancer Research, London Professor Alan Ashworth Targeting PI3K: determinants of sensitivity and resistance to PI3K pathway inhibition
Institute of Nuclear Medicine, University College London Dr Ashley Groves Tumour angiogenesis in breast cancer: correlation between FDG/PET, MRI, CT and histology
King's College, London Dr Maddy Parsons Integrin regulation of fascin-dependent carcinoma cell invasion
King's College, London Professor Anne Ridley Identification of regulators of breast cancer cell invasion and migration
King's College, London Dr Joy Burchell Investigations into the function of the H3K4 demethylase, PLU-1/JARID1B, in breast cancer
King's College, London Dr Jo Armes Triple negative breast cancer: perceptions of prognosis, psychological impact and care needs.
King's College, London Dr Joy Burchell Control of expression of glycosyltransferases involved in O-linked glycosylation in breast cancer
King's College, London Dr Joanna Morris BRCA1 gene variants in breast cancer
Leeds Institute for Molecular Medicine Dr Sandra Bell MCPH1, a potential predictor for response to chemotherapy in breast cancer
Leeds Institute for Molecular Medicine Dr Valerie Speirs Investigating fibroblasts as mediators of breast tumour progression using 3D models
London School of Hygiene and Tropical Medicine Valerie McCormack Mammographic breast density in British young women: natural history and breast cancer prediction
London School of Hygiene and Tropical Medicine Dr Olivia Fletcher Polymorphisms, endogenous hormone levels and familial breast cancer risk in premenopausal women
National University of Ireland Dr Adrienne Gorman Identification of nerve growth factor (NGF)/p75NTR proximal adaptors in breast cancer cells
Queen Mary University of London Dr Richard Grose Investigating FGF signalling in breast cancer
Queen's University, Belfast Dr Konstantin Panov A role for tumour suppressor BRCA1 in the regulation of ribosome biogenesis
Queen's University, Belfast Dr Jennifer Quinn To investigate BRCA1-associated transcriptional regulation of Bcl2 as a mechanism of resistance to DNA damage based chemotherapy
Queen's University, Belfast Dr Kevin Prise NBRCA/FA activation by radiation-induced DNA damage in non-targeted breast cancer cells
Queen's University, Belfast Dr Paul Mullan Characterisation of p63 as a BRCA1 transcriptional target
Queen's University, Belfast Dr Jennifer Quinn Identification and characterisation of BRCA1 associated DNA damage dependent transcriptional targets
Royal College of Surgeons in Ireland Dr Marie McIlroy Transcription factor HOXC11, a novel SRC-1 binding partner; new pathways in endocrine resistance
St Mary's Hospital Manchester Professor Gareth Evans Mammographic surveillance in women aged 35-39 at enhanced familial risk of breast cancer
University College Cork Professor Rosemary O'Connor Regulation of IGF-I and Adhesion Signalling in Breast Cancer
University College London Dr Kerry Chester Novel agents for imaging HER2 positive breast cancer
University of Birmingham Dr Fedor Berditchevski Investigation into the role of tetraspanin6 (Tspan6) in tumourigenesis and metastasis in breast cancer
University of Birmingham Dr Padma-Sheela Jayaraman Modulation of breast tumour size by growth inhibitory protein PRH
University of Birmingham Dr Fedor Berditchevski Investigation of the CD9-dependent regulation of stability of cellular proteins in breast cancer cells
University of Birmingham Dr Farida Latif Functional characterization and role of the SLIT-ROBO gene family in breast cancer development
University of Bristol Dr Claire Perks IGFBP-2: A novel regulator of PTEN. Understanding its role in breast cancer
University of Bristol Dr Ian Paterson The development of small molecule TGF-ß antagonists to inhibit metastatic breast cancer
University of Cambridge Dr Christine Watson Lineage determining pathways and components in mammary stem cells and breast tumours
University of Cambridge Professor Jim Metcalfe Endothelial ALK1/ALK5 receptor signalling effects on breast tumours
University of Cambridge Dr Paul Pharoah Clinical data annotation of a large, population-based series of breast cancer cases
University of Cambridge Dr Paul Edwards Chromosome rearrangements and fusion genes in breast cancer
University of Cambridge Dr Christine Watson The role of caspases in mammary gland development and breast tumourigenesis
University of Cambridge Dr Ruth Warren POSH study - correlation of radiological features of breast cancer in women under 40 years with genetic, pathological and outcomes information
University of Cambridge Dr Paul Edwards Finding new genes in breast cancer by mapping chromosome translocations
University of Cardiff Dr Richard Clarkson The role of caspase-dependent cell death in a model of breast cancer
University of Cardiff Dr Iain Hutcheson Investigation of insulin receptor substrate-1 (IRS-1) as a signalling intermediate for erbB receptors in breast cancer
University of Dundee Dr Colin Palmer Transgenic models of Breast cancer promotion by Peroxisome Proliferator-Activated Receptor delta (PPAR)
University of Dundee Mr Colin McCowan A community-based longitudinal study on adherence to endocrine therapy and cancer outcomes
University of Dundee Dr David Meek Role of Mage-A proteins in suppressing TP53 function in breast tumour development
University of Dundee Dr Mark Saville Identification of components of the ubiquitin system as targets for therapeutic intervention
University of Dundee Dr Jean-Christophe Bourdon Characterisation of p53 isoforms expression in breast cancer
University of Dundee Dr Frances Fuller-Pace Estrogen receptor alpha co-activation by p68 and its role in breast cancer.
University of East Anglia Professor Dylan Edwards Degradomic analysis of ADAMTS-15 targets in breast cancer
University of Edinburgh Dr Maura Wallace Regulation of the ubiquitination and degradation of Numb in breast cancer
University of Edinburgh Professor Ian Kunkler BIG 3-07 DCIS (Ductal carcinoma in situ) boost trial
University of Greenwich Professor Roslyn Corney Impact of breast cancer on couple and family relationships: a pilot study
University of Kent Professor William Gullick Quantum Dot-labelled antibodies to quantify expression of the EGF receptor family in breast cancer specimens
University of Leeds Dr Martin Stacey The role of aberrant leukocyte receptor expression by breast carcinomas
University of Leeds Dr Laura Smith Markers of poor-response to radiotherapy in breast cancer
University of Leicester Dr Paul Symonds Genetic and radiobiological causes of normal tissue damage following breast cancer radiotherapy
University of Leicester Prof Rosemary Walker Altered myoepithelial cell function in cancer - containing breasts - a new risk marker?
University of Manchester Dr William Newman Pharmacogenetics of aromatase inhibitors in breast cancer
University of Manchester Dr Andrew Gilmore The role of focal adhesion kinase in breast cancer initiation
University of Manchester Dr Keith Brennan Role of Notch signalling in acquired apoptosis resistance in mammary epithelial cells
University of Manchester Dr Katrina Lavelle What role do older breast cancer patients play in decisions about surgery?
University of Manchester Professor Charles Streuli Integrins and breast cancer progression
University of Manchester Dr Rachel Cowen Opticin: A potent anti-angiogenic/anti-proliferative agent for breast cancer therapy
University of Manchester Dr Robert Clarke Survival and self-renewal signalling pathways in human breast cancer stem cells
University of Manchester Dr Andrew Gilmore The regulation of anoikis by the Bcl-2 protein, Bid.
University of Newcastle Dr Luke Gaughan Examining a role for histone methyltransferases and demethylases in estrogen-dependent breast cancer
University of Nottingham Professor Sue Watson Temporal analysis of epithelial: mesenchymal transition induced breast cancer models
University of Nottingham Dr Lodewijk Dekker PKC- protein interactions in breast cancer metastasis
University of Nottingham Dr Stewart Martin The thioredoxin and related redox systems as targets in breast cancer
University of Oxford Dr Stephan Feller GEP100 PH domain binding to EGFR drives breast cancer metastasis
University of Oxford Dr Madalena Tarsounas Roles of BRCA1 and BRCA2 Tumour Suppressors in Telomere Maintenance
University of Sheffield Professor Nicola Brown Bevacizumab response in breast cancer - are neuropilins the key?
University of Sheffield Professor Alan Pockley Hsp70, the breast tumour microenvironment and immunoregulatory T cells
University of Sheffield Professor Hilary Powers Generation and validation of a breast cell model of MTHFR C677T mutation
University of Sheffield Dr Ingunn Holen Effects of combined drug treatments on breast tumours in vivo
University of Sheffield Professor Claire Lewis Regulation of the pro-angiogenic functions of Tie-2+ monocytes by angiopietin-2 and hypoxia
University of Southampton Professor Julia Addington-Hall A cohort study of joint pain and stiffness in primary breast cancer
University of Southampton Professor Andrew Collins Novel approaches to meta-analysis and application to genome-wide data sets
University of Southampton Dr Jeremy Blaydes CtBP proteins: role and regulation in breast cancer response to chemotherapy
University of St Andrews, Fife Dr Paul Reynolds Role of polycomb proteins in breast cancer
University of Surrey Dr Richard Morgan Targeting HOX genes in breast cancer
University of Wales, Cardiff Professor Bharat Jasani The value of p53 as a predictive marker of response to chemotherapy in breast cancer
University of West of England Dr Diana Harcourt The psychosocial impact of breast cancer diagnosis amongst BME women
University of Wolverhampton Dr Angel Armesilla Novel molecular approaches to sensitise breast cancer cells to paclitaxel-induced apoptosis