Grant Holder |
Researcher |
Completed project Institute Amount Awarded Duration Type of Award |
Title
Role of ROBO1 (DUTT1) a candidate tumour suppressor gene at 3p12 and its ligands the SLIT genes in breast cancer development
Synopsis
Inactivation of tumour suppressor genes (TSGs) is a critical event in the causation, development and progression of many human cancers. Multiple TSGs have been pinpointed to a particular chromosome in the human cell called 3p12. Within this region a TSG called ROBO1 (DUTT1) has been discovered which may be involved in breast cancer.
Aims & Goals
"Our research is primarily aimed at gaining a greater understanding of the mode of action of BRCA1 and BRCA2 and proteins which are closely associated with them in the normal cells and in breast tumour cells. These investigations will increase our knowledge of the underlying events leading to oncogenesis."
Updates
Professor Farida Latif and PhD student Rachel Dickinson at the University of Birmingham have studied the SLIT family of genes and discovered that they often become damaged in breast cancer. This damage can be reversed with drug treatment and therefore repairing these genes may be a new way to treat breast cancer
Publications
| Title | Epigenetic inactivation of SLIT3 and SLIT1 genes in human cancers |
| Year | 2004 |
| Authors | Dickinson, Dallol A, Bieche I, Dietmar K, Morton D, Maher, ER and Latif F |
Presentations
| Title | Epigenetic inactivation of SLIT genes in human cancers and in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients |
| Year | 2003 |
| Authors | Dickinson R, Dallol A, Bieche I, Krex K, Morton D, Maher ER, Latif F |
| Title | Molecular and Functional analysis of SLIT2 candidate tumour suppressor gene in breast cancer |
| Year | 2004 |
| Authors | Dickinson R, Dallol A, Bieche I, Krex K, Morton D, Maher ER, Latif F |
| Title | Downregulation of CyclinA/CDK2 and upregulation of p21 expression levels and cell cycle arrest in a breast carcinoma cell line following expression of the candidate tumour suppressor gene SLIT2. |
| Year | 2004 |
| Authors | RE Dickinson, A Dallol, F Latif |
