Grant Holder
Dr Andrew Schofield
|
Researcher
Ms Sarah McDonald
|
Completed project
Aberdeen - Scotland
Institute
University of Aberdeen
Amount Awarded
£34,590.00
Duration
36 months
Type of Award
|
Title
Characterisation of genetic events involved in resistance to chemotherapy in breast cancer
Synopsis
Successful treatment with Taxotere, a new and promising drug, leads to cancer cell death by preventing the cells from dividing. However, only about half of all breast cancers respond to such therapy and the treatment has serious side effects such as allergic reactions and abnormally low numbers of white blood cells. Dr Schofield’s project aims to identify which patients are most likely to benefit from the treatment through identifying genetic factors involved with chemotherapy resistance.
Aims & Goals
We are trying to understand why some breast cancer patients do not respond to chemotherapy treatment.
By understanding the mechanisms this will hopefully enable us to develop strategies to overcome drug resistance and to target chemotherapy to patients who are most likely to benefit.
Updates
Dr Andrew Schofield and PhD Student Sarah MacDonald at Aberdeen University have found out why the chemotherapy drug docetaxel does not work for some breast cancer patients. By looking at human genetic material they discovered that breast cancer cells with changes to chromosome 7 and 10 were resistant to docetaxel. Chemotherapy can have serious side effects and this information could allow clinicians to ascertain which breast cancer patients are likely to benefit from treatment before administering it.
Publications
| Title |
Comparative genomic changes associated with docetaxal resistance in breast cancer cell lines |
| Year |
2003 |
| Authors |
McDonald SL, Babalghith AO, Brown I, Moir SE, Stevenson DAJ, Heys SD, Schofield AC |
| Title |
Characterisation of docetaxal resistance in breast cancer cell lines |
| Year |
2003 |
| Authors |
McDonald SL, Moir SE, Babalghith AO, Stevenson DAJ, Heys SD, Wallace HM, Schofield AC |
| Title |
Bcl-2 expression in a docetaxal resistant breast cancer cell line |
| Year |
2003 |
| Authors |
Brown I, McDonald SL, Moir SE, Heys SD, Schofield AC |
| Title |
A novel mechanism of HER2 is not involved in resistance to docetaxal in breast cancer cell lines |
| Year |
2003 |
| Authors |
Shalli K, Brown I, Moir SE, Heys SD, Schofield AC |
| Title |
Amplification of HER2 is not involved in resistance to docetaxal in breast cancer cell lines |
| Year |
2003 |
| Authors |
McDonald SL, Stevenson DAJ, Heys SD, Schofield AC |
| Title |
Detection of a common amplification of 7q in docetaxal resistant breast cancer cell lines by comparative genomic hybridization |
| Year |
2003 |
| Authors |
McDonald SL, Moir SE, Stevenson DAJ, Heys SD, Schofield AC |
| Title |
Molecular changes involved in docetaxal resistance in breast cancer cell lines |
| Year |
2003 |
| Authors |
Brown I, Moir SE, Heys SD, Schofield AC |
| Title |
Molecular changes associated with docetaxal resistance in breast cancer cell using cDNA microarray analyses |
| Year |
2003 |
| Authors |
Brown I, Moir SE, Heys SD, Schofield AC |
| Title |
P-glycoprotein over-expression indicates resistance to docetaxel in human breast cancer
cells. |
| Year |
2003 |
| Authors |
McDonald S, Moir S, Wallace HM, Schofield AC. |
| Title |
Identification of the molecular mechanisms of docetaxal resistance in breast cancer cells |
| Year |
2004 |
| Authors |
Schofield AC, McDonald SL, Shalli K, Brown I, Heys SD |
| Title |
Reduced expression of p27 is a novel mechanism of docetaxal resistance in breast cancer cells |
| Year |
2004 |
| Authors |
Brown I, Shalli K, McDonald SL, Moir SE, Hutcheon AW, Heys SD, Schofield AC |
| Title |
Genomic changes identified by comparative genomic hybridisation in docetaxel resistant breast cancer cell lines. |
| Year |
2005 |
| Authors |
McDonald SL, Stevenson DAJ, Moir SE, Hutcheon AW, Haites NE, Heys SD, Schofield AC |
| Title |
Modulation of p27 expression can alter docetaxel-induced cytotoxicity in breast cancer cells |
| Year |
2005 |
| Authors |
Brown I, Fragiadaki M, McDonald S, Heys SD, Schofield AC |
| Title |
Identification of minimal regions of genomic alteration associated with docetaxel resistance in breast cancer cells |
| Year |
2005 |
| Authors |
McDonald S, Chipchase H, Needham M, Wallace J, Stevenson D, Heys SD, Brown I, Schofield AC |
Presentations
| Title |
P-glycoprotein over-expression indicates resistance to docetaxel in human breast cancer
cells. |
| Year |
2002 |
| Authors |
McDonald S, Moir S, Wallace HM, Schofield AC. |
| Title |
Amplification of 7q is involved in resistance to docetaxal chemotherapy in breast cancer |
| Year |
2003 |
| Authors |
McDonald SL, Moir SE, Stevenson DAJ, Heys SD, Schofield AC |
| Title |
Downregulation of p27 protein is a common event in resistance to docetaxal |
| Year |
2003 |
| Authors |
Brown I, Moir SE, Hutcheon AW, Heys SD, Schofield AC |
| Title |
Molecular changes associated with docetaxal resistance in breast cancer cells using cDNA microarray analyses |
| Year |
2003 |
| Authors |
Brown I, Moir SE, Heys SD, Schofield AC |
| Title |
Detection of common amplification of 7q in docetaxal resistant breast cancer cell linesny comparative genomic hybridization. |
| Year |
2003 |
| Authors |
McDonald SL, Moir SE, Stevenson DAJ, Heys SD, Schofield AC |
| Title |
Molecular changes involved in docetaxal resistance in breast cancer cells |
| Year |
2003 |
| Authors |
Brown I, Moir SE, Heys SD, Schofield AC |
| Title |
Characterisation of docetaxel resistant breast cancer cell lines. |
| Year |
2003 |
| Authors |
McDonald SL, Moir SE, Babalghith AO, Stevenson DAJ, Heys SD, Wallace HM, Schofield AC |
| Title |
Bcl-2 overexpression in a docetaxel resistant breast cancer cell line. |
| Year |
2003 |
| Authors |
Brown I, McDonald SL, Moir SE, Heys SD, Schofield AC. |
| Title |
Identification of genes associated with docetaxel resistance in breast cancer cells from chromosomes 7 and 10 |
| Year |
2005 |
| Authors |
McDonald SL, Wallace JN, Heys SD, Schofield AC |
| Title |
Identification of minimal regions of genomic alteration associated with docetaxel resistance in breast cancer cells |
| Year |
2005 |
| Authors |
McDonald S, Chipchase H, Needham M, Wallace J, Stevenson D, Heys SD, Brown I, Schofield AC |
| Title |
Modulation of p27 expression can alter docetaxel-induced cytotoxicity in breast cancer cells |
| Year |
2005 |
| Authors |
Brown I, Fragiadaki M, McDonald S, Heys SD, Schofield AC |
| Title |
Reversing docetaxel resistance in breast cancer the p27 protein |
| Year |
2006 |
| Authors |
Brown I, Fragiadaki M, Suddason T, Heys SD, Schofield AC |
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