Grant Holder
Dr Ingunn Holen
|
Researcher
Dr Helen Neville-Webbe
|
Completed project
Sheffield - Midlands, South Yorkshire
Institute
University of Sheffield
Amount Awarded
£99,960.00
Duration
36 months
Type of Award
|
Title
Advantages of combined treatment with zoledronic acid and cytotoxic drugs in breast cancer
Synopsis
Breast cancer patients frequently undergo treatment using a combination of different drugs, and in many cases we do not know exactly how these combinations affect the tumour cells. Dr Holen will investigate combinations of frequently used drugs with zoledronic acid, which is used to treat effects of cancer once it has spread to the bone, in order to identify the most effective treatments for patients.
Aims & Goals
"We will investigate the optimal conditions for use of combined treatments and this could potentially be of great benefit for patients. We are looking at compounds already in clinical use, to see how they can be combined most effectively to give better results compared to when they are given individually".
Updates
Dr Ingunn Holen and Dr Helen Neville-Webb at the University of Sheffield have discovered that the order in which different breast cancer drugs are administered greatly affects the number of breast cancer cells killed in the laboratory. This has great potential for improving the way breast cancer patients are treated in the future. This research was published in the International Journal of Cancer (113 (3): 364-371).
Publications
| Title |
Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis |
| Year |
2004 |
| Authors |
Neville-Webbe HL, Cross NA, Eaton CL,, Nyambo R, Evans CA, Coleman RE and Holen I |
| Title |
The role of bisphosphonates in breast and prostate cancers |
| Year |
2004 |
| Authors |
Brown J, Neville-Webbe HJ, and Coleman RE |
| Title |
Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. |
| Year |
2005 |
| Authors |
Neville-Webbe HL, Rostami-Hodjegan A, Evans CA, Coleman RE, Holen I |
| Title |
Preclinical evidence for the effect of bisphosphonates and cytotoxic drugs on tumour cell invasion. |
| Year |
2005 |
| Authors |
Woodward JK, Coleman RE and Holen I |
| Title |
Osteoprotegerin (OPG) - a potential new role in the regulation of endothelial cell phenotype and tumour angiogenesis? |
| Year |
2005 |
| Authors |
Cross SS, Yang Z, Brown NJ, P Balasubramanian SP, Evans CA, Woodward JKL, Neville-Webbe HL, Lippitt JM, Reed MWR, Coleman RE and Holen I |
| Title |
Mechanisms of the synergistic interaction between the bisphosphonate Zoledronic Acid and the chemotherapy agents Paclitaxel in breast cancer cells in vitro |
| Year |
2005 |
| Authors |
Neville-Webbe HL, Evans CA, Coleman RE and Holen I |
| Title |
The Combined Effects of Zoledronic Acid and Doxorubicin on Breast Cancer Cell Invasion In vitro Anticancer Drugs |
| Year |
2005 |
| Authors |
Woodward JKL, Neville-Webbe HL, Coleman RE and Holen I |
| Title |
Osteoprotegerin (OPG) expression by breast cancer cells in vitro and breast tumours in vivo - a role in tumour cell survival? |
| Year |
2005 |
| Authors |
Holen I, Cross SS, Neville-Webbe HL, Cross NA, Balasubramanian SP, Croucher PI, Evans CA, Lippitt JM, Coleman RE and Eaton CL |
| Title |
The use of zoledronic acid in the management of metastatic bone disease and hypercalcaemia |
| Year |
2005 |
| Authors |
Neville-Webbe, HL and Coleman RE |
Presentations
| Title |
Combined treatments of breast cancer cells using Bisphosphonates and Doxorubicin |
| Year |
2004 |
| Authors |
Neville-Webbe H, Evans CA, Coleman RE, Holen I |
| Title |
The combined effects of zoledronic acid (ZOL) and doxorubicin (DOX) on breast cancer invasion in vitro |
| Year |
2005 |
| Authors |
JK Woodward RE Coleman H L Neville-Webbe and I Holen |
| Title |
Zoledonic acid (ZOL) and letrozole (LET) have potential for synergistic induction of apoptosis in breast cancer |
| Year |
2005 |
| Authors |
H L Neville-Webbe R E Coleman and I Holen |
| Title |
Differential induction of apoptosis following sequential treatments using cytotoxic drugs and zoledronic acid |
| Year |
2005 |
| Authors |
CA Evans H L Neville-Webbe R E Coleman and I Holen |
| Title |
Zoledronic acid (ZOL) and letrozole (LET) induce synergistic levels of apoptosis in breast cancer cells |
| Year |
2006 |
| Authors |
H L Neville-Webbe, D Lefley, R E Coleman and I Holen. |
| Title |
Effects of zoledronic acid on apoptosis in tumour cell lines; repeated low dosing compared to continuous treatment |
| Year |
2006 |
| Authors |
I Holen, R Patel, D.V. Lefley, H.L. Neville Webbe, RE Coleman and JKL Woodward. |
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