Grant Holder |
Researcher |
Completed project Institute Amount Awarded Duration Type of Award |
Title
The roles of ADAMTS metalloproteinases in breast cancer
Synopsis
ADAMTS 8 is a protein, which is believed to be a natural inhibitor of tumour growth, but for some reason loses its protective function in breast cancer. Professor Dylan wants to work out what ADAMTS 8 does normally, and whether this loss of function in breast cancer is involved in the change from normal to tumour cell
Aims & Goals
We have identified several genes that appear to be switched off in breast cancer compared to normal breast tissue. We want to determine whether these genes have tumour suppressor functions. In addition, we want to define robust genetic markers that will predict disease outcome in breast cancer patients, and so identify patients who are most at risk; we also want to define the critical targets for therapeutic intervention, potentially developing gene therapy in the case of our gene of interest.
Updates
Professor Dylan Edwards and PhD student Dr Sarah Porter have discovered two new ADAMTS genes which can be used to predict how a patients breast cancer will progress. They hope that these genes can be used by clinicians to tailor treatments to patients more effectively. There results have recently been published in the International Journal of Cancer.
Publications
| Title | The modulation of Matrix Metalloproteinase and ADAM Gene Expression in Human Chondrocytes by Interleukin-1 and Oncostatin M |
| Year | 2002 |
| Authors | Koshy PJT, Lundy CJ, Rowan AD, Porter S, Edwards DR, Hogan A, Clark IM, Cawston TE |
| Title | Expression profiling of metalloproteinases and their inhibitors in cartilage |
| Year | 2003 |
| Authors | Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S, Brockbank SMV, Edwards DR, Parker AE and Clark IM |
| Title | Dysregulated Expression of Adamalysin-Thrombospondin Genes in Human Breast Carcinoma |
| Year | 2004 |
| Authors | Porter S, Scott SD, Sassoon EM, Williams MR, Jones LJ, Girling AC, Ball RY and Edwards D |
| Title | The ADAMTS metalloproteinases |
| Year | 2005 |
| Authors | Porter S, Clark IM, Kevorkian L, Edwards DR |
| Title | ADAMTS8 and ADAMTS15 predict survival in human breast carcinoma |
| Year | 2006 |
| Authors | Sarah Porter, Paul N. Span, C.G.J. (Fred) Sweep, Louk V.A.M. Beex and Dylan R. Edwards |
Presentations
| Title | Profiling Metalloproteinase and TIMP gene expression using TaqMan Quantitative Real-Time PCR |
| Year | 2001 |
| Authors | Sarah Porter, Tony Riddick, Caroline Lundy, Aileen Hogan, Steven Wall, Rob Nuttall, Mary Comer, Maddie Handsley, Pascale Harvey, Damon Bevan and Dylan Edwards. |
| Title | The role of ADAMTS metalloproteinases in breast cancer |
| Year | 2002 |
| Authors | Parker S and Edwards D |
| Title | Profiling the ADAMTS gene family in breast cancer using real-time PCR. |
| Year | 2002 |
| Authors | Sarah Porter, Stuart Scott, Richard Ball and Dylan Edwards. |
| Title | Metalloprotease dysregulation in breast cancer |
| Year | 2004 |
| Authors | Porter S, Pennington C, Jones L and Edwards D |
