(Grant holder Charlotte Coles pictured here (left) with researcher Jenny Wilkinson)

Grant Holder
Dr Charlotte Coles

Researcher
Ms Jenny Wilkinson

Completed project
Ipswich - Anglia

Institute
Addenbrookes Hospital and Ipswich Hospital NHS Trust

Amount Awarded
£89,668.00

Duration
36 months

Type of Award
Project grant

Title

Development of complex radiotherapy techniques in breast cancer

Synopsis

Segmented field radiotherapy (SFRT) is a type of radiotherapy that is though to be better at preventing "hot spots" in health breast tissue, which can lead to breast shrinkage. Dr Coles will compare SFRT with other radiotherapy techniques to see if SFRT produces a better cosmetic result in the breast after treatment.

Aims & Goals

"To investigate whether intensity modulated radiotherapy (IMRT) improves the cosmetic outcome in patients with early breast cancer. To develop the novel use of a 3-D optical camera as: An alternative to computed tomography (CT) for breast IMRT planning. An objective tool to measure breast shrinkage following radiotherapy (RT); a major cause of poor cosmesis. To establish a large database for the future study of single nucleotide polymorphisms (SNPs) for radiosensitivity in breast cancer. "

Updates

In their first year of funding Dr Charlotte Coles and Jenny Wilkinson at Addenbrookes Hospital, Cambridge have developed a National Cancer Research Network trial comparing conventional radiotherapy with a new type called IMR, to see if the new technique produces a better cosmetic result for patients with early breast cancer. They have already recruited over 200 women and hope to have recruited 1000 patients by the end of 2005.

Publications

Title Reduction of radiotherapy-induced late complications in breast cancer: the role of intensity modulated radiation therapy (IMRT) and partial breast irradiation. Part i- Normal tissue complications.
Year 2005
Authors Coles CE, Moody AM, Wilson CB and Burnet NG
Title Reduction of radiotherapy-induced late complications in breast cancer: the role of intensity modulated radiation therapy (IMRT) and partial breast irradiation. Part II- Radiotherapy strategies to reduce radiation induced late effects
Year 2005
Authors Coles CE, Moody AM, Wilson CB and Burnet NG
Title Implementation of breast IMRT via a randomised controlled trial: a report of the first year's experience
Year 2006
Authors CE Coles, AM Moody, ACF Hoole, N Twyman, JS Wilkinson, D Routsis CB Wilson and NG Burnet.

Presentations

Title Novel use of a laser camera: an analytical tool to assess post-radiation normal tissue changes.
Year 2002
Authors CE Coles, N Twyman, A Hoole, AM Moody and NG Burnet and CB Wilson.
Title Innovative use of a laser camera for 3-dimensional breast radiotherapy planning.
Year 2002
Authors CE Coles, N Twyman, A Hoole, AM Moody and NG Burnet and CB Wilson.
Title Forward-planned breast intensity modulated radiotherapy (IMRT): a novel method using a 3-D laser camera.
Year 2003
Authors CE Coles, AC Hoole, N Twyman, J Wilkinson, CB Wilson and AM Moody.
Title Implementation of breast IMRT via a randomised controlled trial: a report of the first year’s experience
Year 2004
Authors Coles CE, Moody AM, Hoole ACF, Twyman N, Wilkinson JS, Routsis D, Wilson CB and Burnet NG
Title The Cambridge Breast IMRT Trial: linking with translational radiogenomics
Year 2005
Authors Charlotte E Coles, A Margaret Moody, Jennifer S Wilkinson, Andrew CF Hoole, Nicola Twyman, Charles B Wilson, Catharine West, and Neil G Burnet.

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