Grant Holder
Professor Mitch Dowsett

Researcher
Dr Lila Zabaglo

Completed project
London - London & South East England

Institute
Royal Marsden & Institute of Cancer Research, London

Amount Awarded
£100,823.00

Duration
24 months

Type of Award
Project grant

Title

Cell filtration-laser scanning cytometry for characterisation of circulating breast cancer cells

Synopsis

Professor Dowsett and his group have developed a method to detect breast cancer cells travelling through the body in the blood stream. This research hopes to actually identify these breast cancer cells, and examine them for specific features. These features may reveal whether breast cancer will respond to particular treatment once it has started to move around the body.

Aims & Goals

"The detection and isolation of cancer cells in the blood of breast cancer patients will allow us to identify these at highest risk of imminent relapse and to characterise the cells or predict response of patients to specific treatments".

Publications

Title Cell filtration-laser scanning cytometry for the characterisation of circulating breast cancer cells.
Year 2002
Authors Lila Zabaglo, Michael G. Ormerod, Marina Parton, Alistair Ring, Ian E. Smith and Mitch Dowsett.
Title Cell filtration: a simple method to isolate putative cancer cells from the blood of patients with metastatic breast cancer.
Year 2002
Authors Ring AE, Zabalogo L, Ormerod MG, Smith IE, Dowsett M
Title Detection of circulating epithelial cells in the blood of patients with breast cancer: comparison of laser scanning cytomology following cell filtration or immunomagnetic separation with a multiple marker real time RT-PCR assay
Year 2005
Authors Ring A, Zabaglo L, Ormerod MG, Smith IE, Dowsett M

Presentations

Title Identification of putative cancer cells from the blood of patients with breast cancer: a comparsion of three techniques.
Year 2003
Authors Ring AE, Zabaglo L, Ormerod MG, Smith IE, Dowsett M.
Title Cell filtration-laser scanning cytometry for the characterisation of circulating breast cancer cells.
Year 2003
Authors Zabaglo L, Ring AE, Ormerod MG, Smith IE, Dowsett M.
Title Cell filtration: a simple method to isolate putative cancer cells from the blood of patients with metastatic breast cancer.
Year 2004
Authors Ring AE, Zabaglo L, Ormerod MG, Smith IE, M. Dowsett

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