Grant Holder |
Researcher |
Completed project Institute Amount Awarded Duration Type of Award |
Title
Small molecule inhibitors of the BAG-1: HSC/HSP70 interaction
Synopsis
The BAG-1 protein is often present in large quantities in breast cancer. It not only protects breast cancer cells from cell death but actually promotes growth within these cells through binding to a second group. Dr Packham’s project aims to develop small molecules which will interfere with this interaction and thereby promote the death of these cancer cells.
Aims & Goals
Our experiments will provide valuable information about the mechanisms of cancer development and may be exploited to develop new approaches to treatment.
Updates
Dr Graham Packham and PhD student Dr Adam Sharp at the University of Southampton have discovered a potentially new breast cancer drug. This molecule stops a protein called BAG-1 from protecting breast cancer cells from dying.
Publications
| Title | BAG-1 expression and function in human cancer. |
| Year | 2002 |
| Authors | Townsend PA, Brimmell B, Bateman AC, Hague A and Packham G. |
| Title | BAG-1: A Multifunctional regulator of cell growth and survival. |
| Year | 2003 |
| Authors | Townsend PA, Cutress RI, Sharp A, Brimmell M and Packham G. BAG-1: A |
| Title | The Nuclear BAG-1 isoform BAG-1L enhances oestrogen-dependent transcription. |
| Year | 2003 |
| Authors | Cutress RI, Townsend PA, Sharp A, Maison A, Wood L, Lee R, Brimmell M, Mullee MA, Johnson PWM, Royle GT, Bateman AC and Packham G. |
| Title | BAG-1 prevents stress-induced long term growth inhibition in breast cancer cells via a chaperone dependent pathway. |
| Year | 2003 |
| Authors | Townsend PA, Cutress RI, Sharp A, Brimmell M and Packham G. |
| Title | The retinoblastoma protein interacts with BAG-1 in human colonic adenoma and carcinoma derived cell lines. |
| Year | 2003 |
| Authors | Arhel NJ, Packham G, Townsend PA, Collard TJ, Zadeh AM, Sharp A, Cutress RI, Malik K, Hague A, Paraskeva C, Williams AC. |
| Title | BAG-1 in carcinogenesis |
| Year | 2004 |
| Authors | Sharp A, Crabb SJ, Cutress RI, Townsend PA, Packham G |
| Title | BAG-1: A multifunctional pro-survival molecule |
| Year | 2005 |
| Authors | Townsend PA, Stephanou A, Packham G, Latchman DS |
| Title | Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma derived epithelial cells: Implications in colorectal tumour development. |
| Year | 2005 |
| Authors | Barnes, J.D., Arhel, N.J., Lee, S-S., Sharp, A., Al-Okail, M., Packham, G., Hague, A., Paraskeva, C and Williams, A.C. |
Presentations
| Title | BAG-1: A NOVEL THERAPEUTIC TARGET FOR BREAST CANCER? |
| Year | 2002 |
| Authors | Adam Sharp, Ramsey I Cutress, Paul A Townsend, Peter WM Johnson and Graham Packham |
| Title | Novel chemical inhibitors of BAG-1 protein:protein interactions inhibit breast cancer cell growth and MAP kinase activity |
| Year | 2005 |
| Authors | G Packham |
