Grant Holder |
Researcher |
Completed project Institute Amount Awarded Duration Type of Award |
Title
The genetic epidemiology of DNA recombination repair genes in breast cancer
Synopsis
It is likely that genes other than BRCA1 and BRCA2 contribute to breast cancer susceptibility. It is already known that the protein products of these two genes participate with other proteins in the process of DNA repair. A reduction in the efficiency of the repair process may also affect breast cancer susceptibility, and this project will investigate other DNA repair genes and their interaction with the known breast cancer genes.
Aims & Goals
Our work aims to determine whether genes involved in the response to DNA damage, and its repair, are involved in breast cancer. Genes that are identified as being involved would be potential targets for novel therapies and could in the future help us identify which women might benefit from particular treatments
Updates
Dr Angela Cox and Gordon MacPherson at the University of Sheffield have found that women who have a certain form of a gene called caspase- 8 have around a 40% reduced risk of developing breast cancer. Angela has received additional funding from Breast Cancer Campaign to study these findings further. This research was recently published in the Journal of the National Cancer Institute (96: 1866-1869)
Publications
| Title | A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer |
| Year | 2002 |
| Authors | Saeed Raffi, Paul O 'Regan, George Xinarianos, Iman Azmy, Tim Stephenson, Malcolm Reed, Mark Meuth, John Thacker and Angela Cox |
| Title | A naturally occuring mutation in an ATP-binding domain of the recombination repair gene XRCC3 ablates its function without causing cancer susceptibility |
| Year | 2003 |
| Authors | Rafii, S, Lindblom, A, Reed, M, Meuth, M, Cox, A |
| Title | Association of a common variant of the CASP8 gene with reduced risk of breast cancer |
| Year | 2004 |
| Authors | MacPherson G, Healey CS, Teare MD, Balasubramanian SP, Reed MWR, Pharoah PDP, Ponder BAJ, Meath M, Bhattacharyya NP, Cox A |
| Title | Heterozygote excess is repeatedly observed in females at the BRCA2 locus N372H |
| Year | 2004 |
| Authors | Teare MD, Cox A, Shorto J, Anderson C, Bishop DT, Cannings C |
Presentations
| Title | An investigation of the relationship between DNA repair genotype and histopathological subtype in breast cancer |
| Year | 2002 |
| Authors | Angela Cox, Saeed Rafii, George Xinarianos, Iman Azmy, Malcolm Reed, Tim Stephenson, Mark Meuth. |
| Title | “The role of DNA variants of Homologous Recombination Repair genes in sporadic breast cancer” |
| Year | 2002 |
| Authors |
| Title | |
| Year | 2002 |
| Authors |
| Title | |
| Year | 2002 |
| Authors |
| Title | “Polymorphic variation in DNA repair genes and susceptibility to common cancers” |
| Year | 2002 |
| Authors |
| Title | "Exploring genetic susceptibility and gene-gene interactions in breast cancer: genes involved in apoptosis” |
| Year | 2003 |
| Authors | Cox, MacPherson, Bhattacharyya, Balasubramanian, Reed and Meuth. |
