Grant Holder |
Researcher |
Completed project Institute Amount Awarded Duration Type of Award |
Title
Role of macrophages in breast tumour angiogenesis
Synopsis
This project aims to establish the precise role of macrophages (normal cells involved in responses to inflammation) in establishing angiogenesis (new blood vessel growth) within breast tumours, and how this activity is controlled by signals found inside the tumour.
Aims & Goals
We are trying to unravel the method by which tumours develop new blood vessels supplying nutrition. If these can be blocked, we could potentially block tumour growth.
Updates
Important techniques have been established and are now in routine use in Sheffield, and we are confident we will be able to perform all future experiments quickly and efficiently. We have been able to show that in the early stages of our breast tumour model the creation of blood vessels was much greater if the tumour contained human macrophages and we are confident that macrophages do have a role to play in the initiation of angiogenesis. It is possible that this information could be useful in the development of new breast cancer treatments. Professor Nicola Brown's completed BCC project at the University of Sheffield has lead to research collaborations being formed between researchers at the University of Leeds and Sheffield, and Mount Vernon Hospital, London.
Publications
| Title | The role of tumour associated macrophages in tumour progression: implications for new anticancer therapies |
| Year | 2002 |
| Authors | L.Bingle, N.J.Brown and C.E.Lewis |
| Title | Macrophages promote angiogenesis in human breast tumour spheroids in vivo |
| Year | 2006 |
| Authors | L Bingle, CE Lewis, KP Corke, MWR Reed and NJ Brown |
| Title | Role of macrophages in breast tumour angiogenesis in vivo |
| Year | 2006 |
| Authors | Bingle, Reed, Lewis, Brown |
Presentations
| Title | Macrophage infiltration into tumour spheroids stimulates angiogenesis in the dorsal skin fold chamber in vivo |
| Year | 2002 |
| Authors | Bingle L, Corke KP, Reed MWR, Brown NJ, Lewis CE |
| Title | Macrophages stimulate angiogenesis in the dorsal skin fold chamber model |
| Year | 2003 |
| Authors | Bingle L, Corke KP, Reed MWR, Lewis CE, Brown NJ |
| Title | Macrophage infiltration into tumour spheriods stimulates angiogenesis in vivo |
| Year | 2006 |
| Authors | Bingle L, Corke KP, Reed MWR, Lewis CE and Brown NJ |
