Grant Holder |
Researcher |
Completed project Institute Amount Awarded Duration Type of Award |
Title
Identification of novel genes in endocrine resistance of breast cancer
Synopsis
For oestrogen-sensitive breast tumours, tamoxifen has proved a successful therapy. The main problem is the inevitability of escape from effectiveness of tamoxifen. Earlier research indicates that this endocrine resistance is reversible if caught early enough, but to date we lack understanding of the mechanism.
Aims & Goals
Genomics technology has allowed us to find new gene markers never described before in breast. We are now studying their function in loss of oestrogen response in breast cancer cells, with the hope that they can be used to increase the effectiveness of endocrine therapy.
Publications
| Title | Stem Cells and Tissue Homeostasis in Mammary Glands |
| Year | 2005 |
| Authors | Clarke RB and Smith GH |
Presentations
| Title | Regulation of RNA helicase mRNA expression in human breast cancer cells. |
| Year | 2001 |
| Authors |
| Title | Loss of CD63 expression as a prognostic marker in breast cancer. |
| Year | 2001 |
| Authors |
| Title | Regulation of CD63 protein in human breast cancer cells |
| Year | 2003 |
| Authors | Shaw LE & Darbre P |
| Title | Identification of novel genes associated with endocrine resistance in breast cancer |
| Year | 2004 |
| Authors | Sadler A.J. & Darbre P.D |
| Title | Expression of the GATA family of transcription factors in human breast cancer cell lines |
| Year | 2004 |
| Authors | Sadler A.J, Shaw L.E. & Darbre P.D. , |
