Grant Holder
Dr Elena Klenova
|
Researcher
Dr France Docquier
|
Completed project
Essex - Anglia
Institute
University of Essex
Amount Awarded
£138,925.00
Duration
36 months
Type of Award
Project grant
|
Title
The role of a transcription factor, CTCF, in breast tumorigenesis
Synopsis
The quest to discover more breast cancer related genes has identified a gene called CTCF which has a negative effect on cell growth. Mutations in this gene have been found in families with a high risk of cancer. This project will investigate such mutations and also the gene’s interaction with other proteins to see if these interactions are involved in CTCF’s role in tumour formation.
Aims & Goals
Finding and characterising the genes involved in breast cancer development is instrumental for
cancer diagnosis, prognosis and treatment. Our goal is to understand how these genes and their
mutated counterparts functions in normal tissues and tumours so that the appropriate cure
could be produced.
Updates
In their final report Dr Elena Klenova and Dr France Docquier at the University of Essex have discovered two potential biomarkers ,called CTCF and BORIS, that may be used for in diagnosis, prognosis and treatment of breast cancer. Dr Klenova has recently received additional BCC funding to study CTCF further.
Publications
| Title |
BORIS, a novel male germline-specific protein associated with epigenetic reprogramming events, shares the same 11 Zn-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma |
| Year |
2002 |
| Authors |
Loukinov DI, Pugacheva E, Vatolin S, Pack SD, Moon H, Chernukhin I, Mannan P, Larsson E, Kanduri C , Vostrov A, Cui H, Niemitz EL, Rasko JEL, Docquier FM, Kistler M, Breen J, Zhuang Z, Quitschke W, Renkawitz R, Klenova EM, Feinberg AP, Ohlsson R, Morse |
| Title |
The novel BORIS+CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer |
| Year |
2002 |
| Authors |
Klenova E, Morse HC, Ohlsson R, Lobanenkov VV |
| Title |
BORIS, a cancer-testis gene that shares an 11 zinc finger DNA-binding domain with the tumor suppressor gene CTCF, is aberrantly expressed in multiple myeloma. |
| Year |
2002 |
| Authors |
Xiang S, Lee CH, Pack S, Docquier F, Vatolin S, Klenov E, Kuehl M, Barlogie B, Hardin J, Zhan F, Loukinov D, Ohlsson R, Lobanenkov V, Shaughnessy J.Jr,. Morse,S |
| Title |
YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders. |
| Year |
2004 |
| Authors |
Klenova E, Scott AC, Roberts J, Shamsuddin S, Lovejoy LA, Bergmann S, Bubb VJ, Royer H-D, Quinn JP |
| Title |
CTCF interacts with the largest subunit of RNA Polymerase II constitutively in vitro and in a sequence-specific context in vivo: Implications for the mechanism of the chromatin insulator function and the origin of intergenic, non-coding transcripts |
| Year |
2004 |
| Authors |
Chernukhin I, Shamsuddin S, Bergström R, Yu W, Whitehead J, Mukhopadhyay R, Docquier F, Kang SY, Vigneron M, Wu S-Y, Chiang C-M, Loukinov D , Lobanenkov V, Ohlsson R and Klenova E |
| Title |
Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. |
| Year |
2005 |
| Authors |
Yu W, Ginjala V, Pant V, Chernukhin I, Whitehead J, Docquier F, Farrar D, Tavoosidana R, Mukhopadhyay R, Kanduri C, Oshimura M, Feinberg AP, Lobanenkov V, Klenova E and Ohlsson R |
| Title |
CTCF regulates growth and erythroid differentiation of human myeloid leukemia cells. |
| Year |
2005 |
| Authors |
Torrano V, Chernukhin I, Docquier F, Leon J, Klenova E, Delgado D. |
| Title |
Heightened expression of CTCF in breast cancer cells is associated with resistance to apoptosis. |
| Year |
2005 |
| Authors |
Docquier F, Farrar D., D'Arcy V, Chernukhin I, Robinson AF, Loukinov D, Vatolin S, Pack S, Mackay A, Harris RA, Dorricott H, O’Hare MJ, Lobanenkov V, Klenova E. |
| Title |
Regulation of the transcription factor, CTCF, by phosphorylation with protein kinase CK2 |
| Year |
2005 |
| Authors |
El-Kady A and Klenova E. |
| Title |
Poly(ADP-ribosyl)ation and epigenetics: Is CTCF PARt of the plot? |
| Year |
2005 |
| Authors |
Klenova E. and Ohlsson R. |
Presentations
| Title |
A novel candidate tumour suppressor, an eleven Zn fingertranscription factor, CTCF |
| Year |
2001 |
| Authors |
Docquier F, Chernukhin JEJ, Rasko J, Leon Gn, Filippova YJ, Hu LM, Mueller AF, Robinson VV, Lobanenkov EM, Klenova EM |
| Title |
Study on expression of a transcription factor, CTCF, in cell lines and tumours. |
| Year |
2004 |
| Authors |
I.V. Chernukhin, F. Docquier, A.F. Robinson, A. Mackay, R.A. Harris, H. Dorricott, M.J. O'Hare and E.M. Klenova |
| Title |
Characterisation of CTCF isoforms found in normal and tumour breast tissue and cell lines. |
| Year |
2004 |
| Authors |
D.Farrar, I.Chernukhin, F.Docquier, V.D'Arcy and E.Klenova |
| Title |
Aberrant expression of BORIS in breast cancer cell lines and tumours |
| Year |
2004 |
| Authors |
I. Chernukhin, V. D'Arcy, F. Docquier, S. Pack, D. Farrar, V. Lobanenkov and E. Klenova |
| Title |
The role of CTCF and BORIS in breast tumourigenesis. |
| Year |
2004 |
| Authors |
E.Klenova, I.Chernukhin, F.Docquier, V.D'Arcy, D.Farrar, S.Raj, D.Loukinov, V.Lobanenkov |
| Title |
CTCF over-expression may protect breast cancer cells from apoptosis |
| Year |
2006 |
| Authors |
F.Docquier, I. Chernukhin, D. Farrar, V. D'Arcy, D. Loukinov, S. Vatolin, V. Lobanenkov and E. Klenova |
| Title |
Expression of a transcription factor, CTCF, and its paralogue, BORIS, during mouse spermatogenesis. |
| Year |
2006 |
| Authors |
Docquier F, Mariano P, Parvinen M, Lobanenkov V, Ohlsson, R, Klenova E |
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