Grant Holder |
Researcher |
Current project Institute Amount Awarded Duration Type of Award |
Title
The role of notch in the development and progression of ductal carcinoma in situ (DCIS)
Aims & Goals
Dutal carcinoma in situ is an early premalignant lesion which now constitutes 30% of breast cancers detected by mammographic screening. We aim to determine how a cancer causing Gene CerbB2 causes progression to invasive cancer in combination with a stem cell marker Notch in DCIS and the role of Notch receptors in the growth of DCIS stem cells.
Presentations
| Title | Ductal carcinoma in situ (DCIS) mammosphere formation; effect of epidermal growth factor (EGF) and notch signalling pathways on self renewal capacity. |
| Year | 2005 |
| Authors | Farnie, G., K. Brennan, R. B. Clarke, and N. J. Bundred |
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