Grant Holder
Dr Robert Clarke

Researcher
Kath Spence

Current project
Manchester - Northern England

Institute
University of Manchester

Amount Awarded
£127,645.00

Duration
36 months

Type of Award
Project grant

Title

Identification of signalling pathways that regulate human breast stem cells

Synopsis

Breast stem cell research has great potential to lead to new methods of breast cancer prevention for those at risk, and new treatment for existing breast cancer patients. This exciting new project will study the potential involvement of breast stem cells in breast cancer development. This work may uncover a new way in which breast cancer develops and therefore identify new approaches of how to prevent it

Aims & Goals

Our work on breast stem cells aims to find new signalling pathways important for their regulation. These may reveal new drug targets for prevention and/or treatment of breast cancer.

Presentations

Title Ductal carcinoma in situ (DCIS) mammosphere formation; effect of epidermal growth factor (EGF) and notch signalling pathways on self renewal capacity.
Year 2005
Authors Farnie, G., K. Brennan, R. B. Clarke, and N. J. Bundred
Title The origins of ER+ and ER- breast cancer
Year 2005
Authors Clarke R
Title Isolation and characterization of human mamary stem cells
Year 2006
Authors Clarke R

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