Grant Holder
Dr Stephen West

Researcher
Dr Yilun Liu

Completed project
London - London & South East England

Institute
Clare Hall Laboratories (Cancer Research UK), South Mimms

Amount Awarded
£99,832.00

Duration
36 months

Type of Award
Project grant

Title

Identification of novel recombination/repair factors and their role in tumour avoidance

Synopsis

For a small percentage of the population, inheriting a mutated BRCA2 gene will increase their risk of developing breast cancer. This project will investigate how mutations in this gene lead to breast cells developing into breast cancer so that we may prevent these events from happening.

Aims & Goals

"Homologous recombination plays a critical role in maintaining the integrity of our chromosomal material and thereby prevents tumourigenesis. Mutations in homologous recombination proteins such as BRCA2, RAD51C and XRCC3 have been detected in individuals with breast cancer. Understanding their functions will allow us to have a better knowledge of breast cancer development and prevention."

Publications

Title CDK-dependent phosphorlation of BRCA2 as a regulatory mechanism for recombinational repair
Year 2005
Authors Esashi, F. , Christ, N., Gannon, J., Liu, Y., Hunt, T., Jasin, M & West, S.
Title BRCA2 BRC motifs bind RAD51-DNA filaments
Year 2005
Authors Glakin, V., Esashi, F., Xiong, Y., Shixin, Y., West, S. & Egelman, E.

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