Grant Holder |
Researcher |
Completed project Institute Amount Awarded Duration Type of Award |
Title
Genetic and biochemical characterization of BRAC1/BARD1 orthologues in C.elegans
Synopsis
Dr Boulton and his team are looking at a version of the breast cancer gene BRCA1which is found in the nematode worm. They hope to be able to better understand what can go wrong to cause breast cancer in humans and identify new factors that increase the risk of developing the disease.
Aims & Goals
Our work aims to identify genes or pathways that when inactivated confer synthetic lethality in combination with BRCA1 mutations. Ultimately this work may lead to treatments that selectively kill tumour cells.
Updates
Dr Simon Boulton and his team at Clare Hall Laboratories, South Mimms, have spent their first year looking at how the breast cancer causing gene BRCA1 works in an animal model - the nematode worm. They have found new proteins that work alongside BRCA1, and are also involved in DNA repair. This finding of this project will provide us with a better understanding of the causes of breast cancer and identify any new factors that might increase the risk of developing the disease.
Publications
| Title | Distinct modes of ATR activation after replication stress and DNA double strand breaks in C. elegans |
| Year | 2005 |
| Authors | Tatiana Garcia-Muse and Simon J. Boulton |
Presentations
| Title | Elucidating the function of the BRCA tumour suppressor genes in C elegans |
| Year | 2004 |
| Authors | Boulton, S |
| Title | Elucidating the function of the BRCA tumour suppressor genes in C elegans |
| Year | 2004 |
| Authors | Boulton, S |
| Title | Elucidating the function of the BRCA tumour suppressor genes in C elegans |
| Year | 2004 |
| Authors | Boulton, S |
| Title | Elucidating the function of the BRCA tumour suppressor genes in C elegans |
| Year | 2005 |
| Authors | Boulton, S |
| Title | Elucidating the function of the BRCA tumour suppressor genes in C elegans |
| Year | 2005 |
| Authors | Boulton, S |
