Grant Holder |
Researcher |
Completed project Institute Amount Awarded Duration Type of Award |
Title
Investigation of the properties of isolated human stem cells
Synopsis
The risk of breast cancer is related partly to the balance between cell exposure to factors which promote cancer cell growth, such as oestrogen, and those which encourage cell specialisation, such as an early full term pregnancy, which protect against breast cancer. This project aims to discover where such specialisations come from, what controls them and whether the number of such cells correlates with breast cancer risk.
Aims & Goals
"Our hope is that by understanding the biology of normal epithelium, in particular the stem cells, we will become better at prevention of breast cancer and also reveal new ways of stopping breast cancer cell growth".
Updates
At a recent visit to the University of Manchester Dr Hedley Coppock updated us on his research looking at breast stem cells in the laboratory. Hedley hopes to find out more about how malfunctioning breast stem cells may become cancerous. By understanding how breast stem cells grow to form mature breast tissue, he may be able to identify new targets for prevention and treatment of breast cancer.
Presentations
| Title | Interaction of cyclin dependent kinase inhibitors and extracellular matrix in regulation of breast epithelial cell differentiation and acinar morphogenesis |
| Year | 2003 |
| Authors | HA Coppock and RB Clarke |
| Title | Co-ordinated levels of p21CIP1/Waf1 and p27KIP1 regulate growth and differentiation of breast epithelial cells |
| Year | 2004 |
| Authors | HA Coppock, DE Gilham and RB Clarke |
| Title | Co-ordinated levels of p21CIP1/Waf1 and p27KIP1 regulate growth and differentiation of breast epithelial cells |
| Year | 2004 |
| Authors | Coppock HA and Clarke R. |
| Title | Co-ordinated levels of p21CIP1/Waf1 and p27KIP1 regulate growth and differentiation of breast epithelial cells |
| Year | 2004 |
| Authors | HA Coppock, DE Gilham and RB Clarke |
