Grant Holder |
Completed project Institute Amount Awarded Duration Type of Award |
Title
The role of SHP-1 in the activation of the nerve growth factor receptor, trkA, by p53 in breast cancer
Synopsis
Dr Montano is looking at three molecules, p53, trkA and SHP-1 to understand how they may all work together to encourage the change of normal cells into breast cancer cells.
Aims & Goals
"This investigation will identify, at the molecular level, the functional consequence(s) and basic mechanism(s) involved during the activation of the nerve growth factor receptor, trkA by the tumour suppressor p53 in breast cancer. The knowledge of these events will provide an increased understanding about the development of breast malignancy as well as pivotal information leading to the production of novel and specific therapeutic agents to target and manage this unique neoplsia"
Updates
At a recent visit to Imperial College, London Dr Ximena Montano told us about her research to unravel the complex story behind how three molecules in a cell work together to control the growth of breast cancer. Dr Montano has found that the molecule p53 could in the future be used as a means of controlling the growth of breast cancer cells through its ability to control the activity of two other molecules SHP1 and trkA. This finding could lead to the development of new drugs to treat breast cancer.
Presentations
| Title | SHP-1 is involved in the activation of trkA by p53 |
| Year | 2005 |
| Authors | Montano, X |
