Grant Holder |
Researcher |
Completed project Institute Amount Awarded Duration Type of Award |
Title
Identification of genes associated with endocrine resistance in breast cancer
Synopsis
The benefits of drugs such as Tamoxifen can wear off in time when tumour cells become resistant to their action. Dr Gee will try to discover the genes that are responsible for this resistance using state of the art microarray techniques, and hopes to identify if these genes responsible could be targeted by breast cancer drugs.
Aims & Goals
Microarray studies will reveal genes that may enable breast tumours to become resistant to anti-hormonal drugs such as Tamoxifen. Such knowledge would allow improved stratification of patients for therapy, and would provide potential targets for the design of effective new treatments for breast cancer sufferers.
Updates
At a recent visit to Cardiff University, Rajpal Burmi, BCC funded PhD student told us about his work which is looking at how breast cancer patients can develop resistance to treatments such as tamoxifen and faslodex over time. He has been using state of the art technology (microarrays) and is on the verge of discovering new genes that have never previously been linked to breast cancer resistance to treatments.
Presentations
| Title | Signal transduction pathways in endocrine resistant breast cancer and their therapeutic implications. |
| Year | 2004 |
| Authors | Gee JMW and Nicholson RI |
| Title | Deciphering the pathways underlying anti-hormone resistance in breast cancer in vitro |
| Year | 2004 |
| Authors | Gee JMW and Nicholson RI |
| Title | Array Profiling of Survival and Resistance Genes in Anti-hormone Treated Breast Cancer Cells |
| Year | 2004 |
| Authors | Gee J, Shaw V, Burmi R, McClelland R, Morgan H, Harper M, Hiscox S, Barrow D, Lewis P, Nicholson R |
| Title | Identification of Genes Associated with Endocrine Resistance in Breast Cancer |
| Year | 2004 |
| Authors | R.S. Burmi, J.M.W. Gee, H.E. Morgan, R.A. McClelland & R.I. Nicholson |
| Title | Revealing new molecular markers to predict for anti-hormonal resistance and to provide future therapeutic targets in breast cancer |
| Year | 2005 |
| Authors | Gee JMW |
| Title | Microarray Studies Reveal Novel Genes Associated with Antiestrogen Resistance in Breast Cancer |
| Year | 2005 |
| Authors | Rajpal S. Burmi, Richard A. McClelland, Robert I. Nicholson, Denise Barrow, Ian O. Ellis, John F. Robertson and Julia M. Gee |
