(Grant holder Dr Grand pictured here with researcher Rachel Bruton)

Grant Holder
Dr Roger Grand

Researcher
Dr Rachel Bruton

Completed project
Birmingham - Midlands, South Yorkshire

Institute
University of Birmingham

Amount Awarded
£140,654.00

Duration
36 months

Type of Award

Title

A possible role for C teminal binding protein in the generation of breast tumors

Synopsis

C terminal binding proteins (CtBPs) interact with other proteins already associated with the generation of breast tumours. This project aims to investigate CtBP and to see if changes to its activity in healthy breast cells could give rise to breast tumours.

Aims & Goals

"Our research is primarily aimed at gaining a greater understanding of the mode of action of BRCA1 and BRCA2 and proteins which are closely associated with them in the normal cells and in breast tumour cells. These investigations will increase our knowledge of the underlying events leading to oncogenesis".

Publications

Title The significance of the CtBP: AdE1A interaction during viral infection and transformation
Year 2006
Authors Grand RJA, Baker C, Barral PM, Bruton RK, Parkhill J, Szestak T and Gallimore P

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