Grant Holder |
Researcher |
Completed project Institute Amount Awarded Duration Type of Award |
Title
The role of the tetraspanin KA1-1/CD82 in signalling induced by ErbB receptors
Synopsis
The protein KA1-1/CD82 is less evident in breast cells where the cancer is spreading. Its presence may suppress the ability of cancer cells to move and metastasise, and this study will investigate the mechanisms of how KA1-1/CD82 regulates such movement and growth.
Aims & Goals
Our overall aim is to establish how KAI1/CD82 affects function of the ErbB receptors, the family of proteins that are overexpressed in up to 30-40% of breast cancers. One of our specific objectives is developing the basis for designing a new class of drugs for treatment of breast cancer."
Updates
In their final report Dr Fedor Berditchevski and Dr Elena Odinstova at the University of Birmingham have found a link between a molecule called KAI-CD82 and ErbB receptors. These could be potential targets for new drugs to prevent breast cancer spreading (metastasis). This project has been funded again by BCC for a further three years.
Publications
| Title | Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR |
| Year | 2003 |
| Authors | Odinstova E, Voortman J, Gilbert E, Berditchevski F, |
Presentations
| Title | Metastasis suppressor, tetraspanin CD82/KA11, is a new regulator of EGF receptor binding properties and dimerisation. |
| Year | 2001 |
| Authors |
| Title | Metastasis suppressor, tetraspanin CD82/KA11, is a new regulator of EGF receptor binding properties and dimerisation. |
| Year | 2001 |
| Authors | Elena Odinstova |
| Title | Tetraspanins as signalling co-factors |
| Year | 2002 |
| Authors | Berditchevski, F |
| Title | Signalling via tetraspanins |
| Year | 2003 |
| Authors |
| Title | The role of CD82 in signalling via EGFR |
| Year | 2003 |
| Authors |
