Grant Holder |
Researcher |
Completed project Institute Amount Awarded Duration Type of Award |
Title
Characterisation and functional analysis of candidate breast tumour suppressor genes from the human chromosomal region 3p21.3
Synopsis
Earlier research has identified eight candidate tumour suppressor genes which may be involved in breast cancer. Characterising these genes and their protein products will determine the role they may play in the formation of breast cancer tumours.
Aims & Goals
We are making encouraging progress investigating tumour suppressor genes involved in breast cancer. A clearer understanding of these TSGs may lead to the development of novel forms of breast cancer therapy.
Updates
Dr Farida Latif, Dr Sarah Fenton and Dr Luke Hesson at the University of Birmingham have identified a major tumour suppressor gene called RASSF1A that often stops working in the early stages of breast cancer development. The genes function can be returned by treatment with particular drugs. This work may help to design new breast cancer treatments and aid in early breast cancer diagnosis in the future.
Publications
| Title | Identification of the E1A-regulated transcription factor p120E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene |
| Year | 2004 |
| Authors | Fenton SL, Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F |
| Title | RASSF1A Interacts with Microtubule-Associated Proteins and Modulates Microtubule Dynamics |
| Year | 2004 |
| Authors | Dallol A, Agathanggelou A, Fenton SL, JAhmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F |
| Title | Identification of the E1A-regulated transcription factor p120E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene |
| Year | 2004 |
| Authors | FentonSL , Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F |
| Title | Transcriptional Regulation of Cyclin A2 by RASSF1A through the Enhanced Binding of p120E4F to the Cyclin A2 Promoter |
| Year | 2005 |
| Authors | Jalal Ahmed-Choudhury, Angelo Agathanggelou, Sarah L. Fenton, Christopher Ricketts, Geoffrey J. Clark, Eamonn R. Maher, and Farida Latif |
| Title | Role Of The Ras Association Domain Family 1 (Rassf1) Tumor Suppressor Gene In Human Cancers. |
| Year | 2005 |
| Authors | Agathanggelou A, Cooper W andLatif F |
| Title | The Tumor Suppressor, RASSF1A and MAP-1 Link Death Receptor Signaling to Bax Conformational Change and Cell Death. |
| Year | 2005 |
| Authors | Shairaz Baksh, Stella Tommasi, Sarah Fenton, Victor Yu, L. Miguel Martins, Gerd Pfeifer, Farida Latif , Julian Downward and Benjamin G. Neel |
Presentations
| Title | Functional analysis of the RASSF1A tumour suppressor gene using yeast two-hybrid screen |
| Year | 2002 |
| Authors | S.L.Fenton, L.B.Hesson, A.Agathanggelou, E.R.Maher, F.Latif |
| Title | Identification of the E1A-regulated transcription factor p120E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene |
| Year | 2004 |
| Authors | SL Fenton, A Dallol, A Agathanggelou, L Hesson, J Ahmed-Choudhury, S Baksh, C Sardet, R Dammann, JD Minna, J Downward, ER Maher, F Latif. |
