Breast Cancer Treatment

Breast Cancer Treatment

When a diagnosis of breast cancer has been made, your doctor will discuss the best treatment for you, the timing of your treatment, and any potential side effects. As well as your diagnosis, treatment decisions will be influenced by factors such as your general health and personal choice.

Breast cancer treatment can include a combination of all, or some of the following treatments:

Surgery

  • Surgery is usually the first treatment and is used to remove cancerous tissue from the breast. The surgery offered will depend on the type of cancer, its size, where it is in the breast and how much of the surrounding tissue needs to be removed
  • The types of surgery offered include a lumpectomy (also known as a wide local excision) or a mastectomy
  • A lumpectomy, or wide local excision, involves removing the cancer and a small amount (margin) of normal tissue around it
  • A mastectomy involves the removal of the entire breast, a modified radical mastectomy also involves removing some of the lymph nodes under the armpit and some muscle from the chest wall
  • For some women at a high-risk of developing breast cancer due to their family history and/or a gene mutation, risk-reducing mastectomy and oophorectomy (removal of the ovaries) is available on the NHS. Find out more about risk-reducing mestectomies.

Radiotherapy

  • Radiotherapy involves destroying cancer cells with a targeted, carefully measured dose of radiation
  • The treatment is usually used to kill any remaining cancer cells after surgery or to reduce the size of tumour before surgery
  • Radiotherapy can also be used to help pain and other symptoms when breast cancer has spread to the bone, brain or lungs

Chemotherapy

  • Chemotherapy is a treatment that uses chemicals to destroy cancer cells by targeting rapidly dividing cells in the body
  • Chemotherapy can be used before surgery to shrink large tumours, after surgery to kill cancer cells that may have spread to other parts of the body, or independently of surgery to slow the growth of secondary cancer
  • As chemotherapy is not specific to cancer cells it can destroy other rapidly dividing cells such as hair follicles and the lining of the gut, and this causes some of the side effects associated with treatment such as hair loss and nausea
  • Treatment is given in the form of tablets or by injection every two to four weeks over a four to six month period

Anti-Hormone therapy

  • Some breast cancers are stimulated to grow by the hormone oestrogen, which attaches to receptors on the surface of cancer cells. These cancers are known as oestrogen receptor positive (ER+)
  • Anti-hormone therapies block oestrogen from binding with oestrogen receptors, or stop the body from producing oestrogen altogether
  • Treatment is taken as a tablet once a day to reduce the long term risk of breast cancer coming back after surgery or chemotherapy
  • Tests can also be done to see if cancer cells are progesterone receptor positive (PR+), although the benefits of anti-hormone therapy for cancers that are only progesterone receptor positive is less clear

Targeted therapy

  • Targeted therapies are a group of drugs that block the growth and spread of cancer by targeting specific molecules present in cancer cells
  • Because these treatments are specific to cancer cells they may be less harmful to normal cells and so can have fewer side effects
  • The most well-known targeted treatment for breast cancer is Herceptin (trastuzumab), which is given to people with abnormally high levels of the protein HER2. These HER2 positive or HER2+ cancer cells are found in around 20 per cent of breast cancers patients
  • Herceptin is given in the form of intravenous injection and can be given after surgery or chemotherapy, or at the same time as chemotherapy, to reduce the chances of breast cancer coming back or spreading

For further information on diagnosis, treatment, and questions you may want to ask your doctor, or visit Breast Cancer Care.

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